Intellectual and Developmental
Disabilities Research Center

Cores & Services


The Administrative Core provides the leadership and coordination that has made the Center an effective and cohesive vehicle to advance IDDRC-related research at CHOP and the University of Pennsylvania.

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Clinical Translational

The Clinical Translational Core (CTC) was mandated by the NIH in order to emphasize translational research. The CTC aims to provide a set of supports to make research more productive and efficient and to foster new clinical investigation.

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Biostatistics & Bioinformatics

The Biostatistics and Bioinformatics Core (BBC) provides comprehensive and expert analytic tools for IDDRC users who require support in biostatistics, experimental design and/or the analysis of the large datasets culled from DNA sequencing and cognate technologies.

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Analytical Neurochemistry

The Analytical Neurochemistry Core (ANC) will enable users to identify and quantify changes in brain biochemistry. Analyses are performed: (a) In vitro; (b) In pre-clinical animal models of intellectual and developmental disabilities (IDD); and (c) In vivo, in human patients.

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Neuroimaging & Neurocircuitry

The Neuroimaging and Neurocircuitry Core (NNC) enables the study of changes in brain circuitry which occur in people with IDD. The Core supports research in both patients and animal models by providing users the following state-of-the-art technologies.

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Preclinical Models

The Preclinical Models Core (PMC) was developed in response to a user survey that emphasized a need for an IDD-focused facility for the study of mammalian behavior and one to address the potential of current stem cell technologies, including genome editing using CRISPR-Cas9.

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